Protopine

Chemical Name: Protopine
CAS No.:130-86-9

Chemical Structure:C20H19O5N 

Molecular weight:353.37

Application：

Analgesic Effect: Possesses notable analgesic properties.

Inhibition of Platelet Aggregation: Capable of inhibiting platelet aggregation, contributing to the prevention of thrombus formation.

Relaxation of Smooth Muscles: Exerts a relaxing effect on smooth muscles, potentially aiding in the alleviation of diseases caused by smooth muscle spasms.

Anti-Arrhythmic Effect: Demonstrates significant actions on the cardiovascular system, including anti-arrhythmic effects.

Anti-Tumor Activity: Possesses anti-tumor activity, inhibiting the growth and spread of tumor cells.

Protection Against Liver Injury: Offers protection to the liver, mitigating chemical or immune-mediated liver damage.

Anti-Inflammatory Effect: Exhibits anti-inflammatory properties, suppressing inflammatory responses.

Antimicrobial Activity: Demonstrates inhibitory effects against certain microorganisms.

Anti-Angiogenesis: Capable of inhibiting angiogenesis, potentially aiding in the suppression of tumor growth and metastasis.

Furthermore, Protopine displays potent anti-cholinesterase (anti-ACHE) activity and serves as a specific, reversible, and competitive inhibitor of acetylcholinesterase (AChE).

IV. Application Research

In vitro studies have shown that Protopine inhibits cell viability, migration, invasion, and EMT processes in hepatocellular carcinoma cells (HepG2, Huh7), exerting its anti-tumor effects through the induction of apoptosis and inhibition of the PI3K/Akt signaling pathway.

In animal experiments, Protopine displays antidepressant-like effects, protects against focal cerebral ischemia injury in rats, and alleviates memory impairment in mice.

In tumor models, Protopine inhibits tumor growth and induces caspase-3 cleavage.