DMSA

Chemical Name: DMSA

CAS No.:304-55-2

Chemical Structure:C4H6O4S2 

Molecular weight:182.22 

DMSA is an organic sulfur compound commonly used as a detoxifying agent for heavy metal poisoning, especially lead poisoning. Its chemical structure contains two thiol groups (SH), which can form stable complexes or chelates with heavy metal ions, helping to remove heavy metals from the body.

The detoxification mechanism of DMSA is primarily achieved through the following aspects:

Complexation:
The thiol groups of DMSA can form stable complexes with heavy metal ions (such as lead, mercury, cadmium, etc.), reducing their biological activity in the body.

Enhanced Renal Excretion:
After complexation, the heavy metal-DMSA complexes are more easily recognized by the kidneys and excreted through urine.

Reduced Intestinal Absorption:
DMSA can also bind to heavy metals in the intestine, reducing their absorption by the intestine.

DMSA is commonly used in the clinical treatment of lead poisoning in children because it has relatively low toxicity to the kidneys of children. However, the use of DMSA still requires caution as it may produce adverse reactions in certain populations, such as those with impaired kidney function.